A: Thanks your for your inquiry! You mentioned that you have IgA Nephropathy, which is an immune-mediated disorder featured by the presence of IgA in the mesangial area of the kidneys. In the early stage, symptoms usually do not occur. And it may take years of decades before patients experience any symptoms.

When it comes to swelling in the ankle, it can be caused by fluid retention and loss of protein. Do you have protein in urine? If so, what does the 24-hour urine protein show? In this regard, you are suggested to limit the intake of salt and protein strictly. Meanwhile, some Western medicines like prednisone, cyclophosphamide, ACE Inhibitors, ARBs, etc are commonly used to reduce the leakage of protein. Even if the therapeutic effect is obvious, kidney damage remains unsolved. What’ s worse, these medicines can do nothing to improve kidney function.

Here, experienced nephrologists of our center recommend patients with the combination of Immunotherapy and Blood Purification. By doing so, IgA depositions in the mesangial area can be expelled and abnormal immune system can be corrected. After a period of systematic treatment, there is a good chance to improve kidney function. For more info, please have a nice chat with our online doctors!

Topic: Live Doctor IgA Nephropathy