A prognosis is an estimate of the future of someone or something, especially about whether a patient will recover from an illness. Chronic nephritis is a progressive glomerular disease. Its prognosis is poor. For chronic nephritis, early treatment and periodic review is required.

The natural course of patients with chronic nephritis changed a lot. It may develop after a long interval during which no symptoms have been present. The condition develops into renal insufficiency for this kind of patients take up to 5 - 6 years or even 20 - 30 years. A handful of patients can relieve itself. Another kind of patients’ condition may develop into kidney failure in only 2-3 years. It is generally believed the sustained hypertension and renal function impairment of chronic nephritis with poor prognosis.

Pathology classification of renal biopsy is accurate for the judgment of the prognosis. It is generally believed the prognosis of minimal change nephropathy and pure mesangial proliferative glomerulonephritis (MSPGN) is favorable. Membranous nephropathy (MN) advances slowly, and its prognosis is favorable. Most cases of MSPGN would cause renal insufficiency within a few years. Focal segmental glomerular sclerosis (FSGS) prognosis is poor. In recent years, studies have shown that in addition to glomerular lesions, the lesion degree of renal tubules, renal blood vessels and renal interstitium affect prognosis more. The prognosis of renal tubular atrophy, hardening of the small blood vessels in the kidneys, cells in renal interstitium infiltrating and interstitial fibrosis are poor.

Clinical observations:

(1) The prognosis of patient with the history of hemolytic streptococcus infection is well.

(2) The prognosis of patient with only proteinuria or blood urine is favorable.

(3) The prognosis of patient with chronic nephritis hypertension model is relatively poor. If blood pressure drop to normal level by using medications, the prognosis is relatively better. A person whose blood pressure is higher than 22.7/14.7 kpa, the prognosis is poor.

(4) Patients with persistent hematuria, deterioration of renal function is rapid.

(5) The prognosis of patient with renal hypofunction and azotemia is poor.

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